COMPOSITE BIOCOMPATIBLE MATERIALS BASED ON CHITOSAN AND CALCIUM PHOSPHATES FOR BONE RECONSTRUCTION

10.25712/ASTU.1811-1416.2025.04.006

Abstract

Bone implant materials play a significant role in modern biomedical materials science due to the increasing incidence of bone diseases. Calcium phosphate-based biocomposites are one of the promising materials in this field. However, these materials in their pure form have a number of drawbacks, such as insufficient biological activity, which opens up the possibility of modifying calcium phosphate cements with polymeric materials that can improve the physicochemical and biological properties of these materials. Thus, in this work, a composite material based on brushite/chitosan and hydroxyapatite/chitosan with a chitosan mass content of 0.05 wt.%; 0.2 wt.%; 0.4 wt.% was synthesized. The phase and component compositions were determined by X-ray diffraction analysis (XRD) and Fourier transform infrared spectroscopy (FTIR). The morphology and structure of the composites were characterized using scanning electron microscopy (SEM). The contact angle and surface energy were measured using the sessile drop method. Solubility was assessed by incubating samples in saline followed by titration. Biocompatibility was tested using human monocytes