SYNTHESIS AND STUDY OF CYTOTOXICITY OF HETEROLIGAND AZOLE-CONTAINING COMPLEXES Cu(II) and Co(II)
NXOUUH
DOI:
https://doi.org/10.25712/ASTU.2072-8921.2025.04.029%20Keywords:
ligands, azoles, complex compounds of copper and cobalt, inorganic salts, 2,2’-bipyridyl, synthesis, cytotoxicity, lymphoma cells, anticancer drugsAbstract
Various heterocyclic structures, including azole-containing coordination compounds of transition metal ions, are part of antitumor drugs. Currently, new methods to synthesize such drugs that damage and destroy rapidly proliferating cancer cells, are being developed. In this work, coordination compounds of copper(II) and cobalt(II) with 1-(benzimidazolyl)- 2-(3,5-dimethylpyrazole-1-yl) ethane, as well as multi-ligand complexes consisting of 2,2’-bipyridyl molecules, were obtained. All complexes have been studied as agents that suppress the proliferation of cancer cells. The study demonstrated that the obtained coordination compounds exhibit cytotoxicity against T-cell type lymphoma cells (JURKAT). It was experimentally established that in the control group (without the addition of the complex), after two days of cultivation in a thermostat, there were 10 times more cells than in the groups with the addition of the complexes. In addition, the obtained coordination compounds showed less cytotoxicity compared to inorganic salts of the corresponding metals, and are expected to have less negative effects on healthy cells, while interfering with the division of cancer cells.
References
ROS-mediated autophagy was involved in cancer cell death induced by novel copper(II) com-plex / Wen-jie Guo [et al.] // Experimental and Toxi-cologic Pathology. 2010. № 5. Vol. 62. P. 577-582. doi: 10.1016/j.etp.2009.08.001.
Terzioglu N., Gursoy A. Synthesis and anti-cancer evaluation of some new hydrazone deriva-tives of 2,6-dimethylimidazo[2,1-b]-[1,3,4]thiadiazole-5-carbohydrazide // European Journal of Medicinal Chemistry. 2003. Vol. 38. P. 781-786. doi: 10.1016/S0223-5234(03)00138-7.
Gursoy A., Karal N. Synthesis and primary cy-totoxicity evaluation of 3-[[(3-phenyl-4(3H)- quinazo-linone-2-yl) mercaptoacetyl]hydrazono]-1H-2-indolinones // European Journal of Medicinal Chem-istry. 2003. Vol. 38. P. 633-643. doi: 10.1016/S0223-5234(03)00085-0.
New α-(N)-heterocyclichydrazones: evalua-tion of anticancer, anti-HIV and antimicrobial activity / Savini L. [et al.] // European Journal of Medicinal Chemistry. 2004. Vol. 39. P. 113–122. doi: 10.1016/j.ejmech.2003.09.012.
Platinum-resistant ovarian cancer: from drug resistance mechanisms to liquid biopsy-based bi-omarkers for disease management / Khan M.A. [et al.] // Semin Cancer Biology. 2021. Vol. 77. P. 99–109. doi: 10.1016/j.semcancer.2021.08.005.
Synthesis and evaluation of anticancer prop-erties of novel benzimidazole ligand and their co-balt(II) and zinc(II) complexes against cancer cell lines A-2780 and DU-145 / Yılma Ü. [et al.] // Inor-ganica Chimica Acta. 2019. Vol. 495. P. 2–7. doi: 10.1016/j.ica.2019.118977.
Transition metal complexes with tetradentate Schiff bases (N2O2) obtained from salicylaldehyde: A review of their possible anticancer properties / Alfon-so-Herrera A. [et al.] // Coordination Chemistry Re-views. 2024. Vol. 505. doi: 10.1016/j.ccr.2024.215698.
Copper complexes in cancer therapy / Denoyer, D. [et al.] // Met. Ions Life Sci. 2018, Vol. 18. P. 469–506. doi: 10.1515/9783110470734-022.
Advances in copper complexes as anticancer agents / Santini, C [et al.] // Chem. Rev. 2014. Vol. 114. P. 815–862.
Anticancer activity of metal complexes: In-volvement of redox processes / Jungwirth U. [et al.] // Antioxid. Redox Signal. 2011. Vol. 15. P. 1085–1127. doi: 10.1089/ars.2010.3663.
Tardito S., Marchiò L. Copper compounds in anticancer strategies // Current Med. Chem. 2009. Vol. 16. P. 1325–1348. doi: 10.2174/092986709787846532.
Copper complexes as anticancer agents / Marzano C. [et al.] // Anticancer Agents Med. Chem. 2009. Vol. 9. P. 185–211. doi: 10.2174/187152009787313837.
Metal-Based Anticancer Agents / Kellett A. [et al.] // Royal Society of Chemistry. 2019. Vol. 14. P. 91–119. doi: 10.1039/9781788016452-00091.
Advances in copper complexes as anti-cancer agents / Antini C. // Chem. Rev. 2014. Vol. 114. P. 815–862. doi: 10.1021/cr400135x.
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Copyright (c) 2025 Galina A. Proskurina, Nina P. Chernova, Irina I. Kulbakina
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