COMPARATIVE CHARACTERISTICS OF THE INFLAMMATORY REACTION DURING IMPLANTATION OF SYNTHETIC POLYMERIC MATERIALS IN EXPERIMENTAL ANIMALS

HZBNHY

Abstract

The paper presents the results of a study of the physico-mechanical, structural characteristics and biocompatibility of polymeric materials for medical purposes - ultra-high molecular weight polyethylene and polyvinylidene fluoride. The polymer samples under study were produced by hot pressing followed by cooling under pressure in a press. Determination of tensile strength, relative elongation, yield strength and tensile modulus was carried out on a universal testing machine. The surface morphology of polymer samples before and after implantation into laboratory rats was studied by scanning electron microscopy. Structural changes in polymers after implantation into the body are noted, expressed in smoothing the surface of polyvinylidene fluoride and an increase in grooves on the surface of a sample of ultrahigh molecular weight polyethylene. The effect of implantation of materials on changes in the functional group composition was studied by infrared (IR) spectroscopy. It is shown that a sample of ultra-high molecular weight polyethylene has new absorption bands related to vibrations of the C-O bond of the carbonyl and epoxy groups. The introduction of a polyvinylidene fluoride implant into the subcutaneous tissue of an animal does not lead to a change in the chemical composition and the formation of new absorption bands, which indicates the bioinertness of the material. The degree of immunogenicity and the nature of inflammatory processes in the tissues of the body around the test material is assessed by surgical implantation into the physiological spaces of laboratory animals. A comparative evaluation of the inflammatory reaction at the site of implantation of polymer implants made of ultra-high molecular weight polyethylene and polyvinylidene fluoride into laboratory rats was carried out. The inflammatory response was assessed by histological samples of the skin around the implants.